In the second half of the 19th century, the Market House was used by a variety of businesses:

1858-1861 – Edward Bradshaw, a Thame linen draper, used the premises as a furniture warehouse, but was declared bankrupt in the 1860s.

1869-1876 – Thomas Avery was an upholster and cabinet maker who traded at the Market House before relocating to 104, High Street.

1877-1879 – William Jenns from Aylesbury was a grocer and tea dealer, but went into liquidation.

1880s – William Howlett ran a wheelwright and coach-building business behind his public house, the Fighting Cocks (1, High Street). He employed ten men, including his two sons. During the 1880s, he appears to have opened an office in Market House, as a trade sign could be seen above the ground-floor east window.